IMPORTANT SAFETY INFORMATION WARNING-IMPORTANT INFORMATION ABOUT COMBINING ESTROGEN AND PROGESTIN: Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older. Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia.

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Frequently Asked Questions (FAQs)

Ask your Healthcare Provider if Climara Pro is right for you.

Learn more below.

What is Climara Pro?

Climara Pro is a prescription medicine patch (Transdermal System) that contains two kinds of hormones, an estrogen and a progestin.

What is Climara Pro used for?

Climara Pro is used after menopause to:

Reduce moderate to severe hot flashes

Estrogens are hormones made by a woman’s ovaries. The ovaries normally stop making estrogens when a woman is between 45 and 55 years old. This drop in body estrogen levels causes the "change of life" or menopause (the end of monthly menstrual periods). Sometimes, both ovaries are removed during an operation before natural menopause takes place. The sudden drop in estrogen levels causes "surgical menopause."

When the estrogen levels begin dropping, some women get very uncomfortable symptoms, such as feelings of warmth in the face, neck, and chest, or sudden, strong feelings of heat and sweating ("hot flashes" or "hot flushes"). In some women, the symptoms are mild, and they will not need to take estrogens. In other women, symptoms can be more severe. You and your Healthcare Provider should talk regularly about whether or not you still need treatment with Climara Pro.

Help reduce your chances of getting osteoporosis (thin weak bones)

If you use Climara Pro only to prevent osteoporosis due to menopause, talk with your Healthcare Provider about whether a different treatment or medicine without estrogens might be better for you. You and your Healthcare Provider should talk regularly about whether you still need treatment with Climara Pro.

Who should not use the Climara Pro patch?

Do not use Climara Pro if you have had your uterus (womb) removed (hysterectomy).
Climara Pro contains a progestin to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not use Climara Pro.

Do not start using Climara Pro if you:

have unusual vaginal bleeding

Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your Healthcare Provider should check any unusual vaginal bleeding to find out the cause.

currently have or have had certain cancers

Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your Healthcare Provider about whether you should use Climara Pro.

had a stroke or heart attack

currently have or have had blood clots

currently have or have had liver problems

have been diagnosed with a bleeding disorder

are allergic to Climara Pro or any of its ingredients

Active ingredient: estradiol and levonorgestrel

Inactive ingredient: acrylate copolymer adhesive, and polyvinylpyrrolidone/vinyl acetate copolymer.

think you may be pregnant

Climara Pro is not for pregnant women. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not use Climara Pro if the test is positive and talk to your Healthcare Provider.

What dosage strength does the Climara Pro patch come in?

The Climara Pro patch contains 0.045 mg per day of estradiol and 0.015 mg per day of levonorgestrel.

What should I tell my Healthcare Provider before I use Climara Pro?

Before you use Climara Pro, tell your Healthcare Provider if you:

have unusual vaginal bleeding

Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your Healthcare Provider should check any unusual vaginal bleeding to find out the cause.

have any other medical conditions

Your Healthcare Provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.

are going to have surgery or will be on bed rest

Your Healthcare Provider will let you know if you need to stop using Climara Pro.

are breastfeeding

The hormones in Climara Pro can pass into your breast milk.

Tell your Healthcare Provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Climara Pro works. Climara Pro may also affect how your other medicines work. Keep a list of your medicines and show it to your Healthcare Provider and pharmacist when you get a new medicine.

What are the possible side effects of Climara Pro?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

  • heart attack
  • stroke
  • blood clots
  • dementia
  • breast cancer
  • cancer of the lining of the uterus (womb)
  • cancer of the ovary
  • high blood pressure
  • high blood sugar
  • gallbladder disease
  • liver problems
  • changes in your thyroid hormone levels
  • enlargement of benign tumors of the uterus (”fibroids”)

Call your Healthcare Provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

  • new breast lumps
  • unusual vaginal bleeding
  • changes in vision or speech
  • sudden new severe headaches
  • severe pains in your chest or legs with or without shortness of breath, weakness and fatigue

Less serious, but common side effects include:

  • headache
  • breast pain
  • irregular vaginal bleeding or spotting
  • stomach or abdominal cramps, bloating
  • nausea and vomiting
  • hair loss
  • fluid retention
  • vaginal yeast infection
  • redness or irritation at the patch placement site

These are not all the possible side effects of Climara Pro. For more information, ask your Healthcare Provider or pharmacist. Tell your Healthcare Provider if you have any side effects that bother you or does not go away.

You may report side effects to Bayer Healthcare Pharmaceuticals at 1-888-842-2937 or to the FDA at 1-800-FDA-1088.

What can I do to lower my chances of a serious side effect with Climara Pro?

  • Talk with your Healthcare Provider regularly about whether you should continue using Climara Pro.
  • See your Healthcare Provider right away if you get vaginal bleeding while using Climara Pro.
  • Have a pelvic exam, breast exam and mammogram (breast X-ray) every year unless your Healthcare Provider tells you something else.
  • If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast exams more often.
  • If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or if you use tobacco, you may have higher chances for getting heart disease. Ask your Healthcare Provider for ways to lower your chances of getting heart disease.

What is Climara Pro® Used For?

Climara Pro® contains two kinds of hormones, an estrogen and a progestin. It is used after menopause in women with an intact uterus to:

  • Reduce moderate to severe hot flashes
  • Help reduce your chances of getting osteoporosis (thin weak bones)
    • If you use Climara Pro only to prevent osteoporosis from menopause, talk with your Healthcare Provider about whether a different treatment or medicine without estrogens might be better for you.

Important Safety Information

What is the most important information I should know about Climara Pro® (combination of estrogen and a progestin)?

  • Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia.
  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Using estrogen-alone may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • You and your healthcare provider should talk regularly about whether you still need treatment with the Climara Pro.

Who should not use Climara Pro?

Do not use Climara Pro if you have had your uterus (womb) removed (hysterectomy). Climara Pro contains a progestin to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and should not use Climara Pro.

Do not start using Climara Pro if you:

Have unusual vaginal bleeding; currently have or have had certain cancers, such as cancer of the breast or uterus; had a stroke or heart attack; currently have or have had blood clots or liver problems; have been diagnosed with a bleeding disorder; are allergic to Climara Pro or any of its ingredients; or think you may be pregnant.

Before using Climara Pro, tell your Healthcare Provider if you:

Have any unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, or are breastfeeding.

What are possible side effects of Climara Pro?

Serious, but less common side effects of Climara Pro include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus (womb), cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, changes in your thyroid hormone levels and enlargement of benign tumors of the uterus (“fibroids”).

Call your Healthcare Provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

New breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Less serious, but common side effects include:

Headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection and redness or irritation at the patch placement site.

These are not all the possible side effects of Climara Pro. For more information, ask your Healthcare Provider or pharmacist. Tell your Healthcare Provider if you have any side effects that bother you or do not go away.

Climara Pro is available by prescription only.


For important risk and use information, including Boxed Warning, about Climara Pro, please see the Full Prescribing Information.