IMPORTANT SAFETY INFORMATION WARNING-IMPORTANT INFORMATION ABOUT COMBINING ESTROGEN AND PROGESTIN: Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older. Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia.

Continue reading below.

How to Apply

Read this Patient Information before you start using Climara Pro and each time you get a refill.

There may be new information. This information does not take the place of talking to your Healthcare Provider about your menopausal symptoms or your treatment.

Product Shot

Step-by-Step Instructions

Pick the days you will change your Climara Pro.

You will need to change your patch 1 time each week, or every 7 days.

Remove the Climara Pro patch from the pouch.

Remove patch from its protective pouch by tearing at the notch (do not use scissors).

Do not remove your patch from the protective pouch until you are ready to apply it.

Remove the adhesive liner.

You will see that Climara Pro is an oval-shaped, clear patch that is attached to a thick, hard-plastic adhesive liner and covered by a clear plastic film.

To apply your patch, you must first remove the protective, clear plastic film that is attached to the clear thicker plastic backing.

There is a silver foil-sticker attached to the inside of the pouch. Do not remove the silver foil-sticker from the pouch.

Placing the patch on your skin.

Apply the sticky side of the patch to one of the areas of skin shown to the right.

Avoid touching the sticky side of the patch with your fingers.

Note:

Avoid the waistline, since clothing and belts may cause the patch to be rubbed off.

Do not apply Climara Pro to your breasts.

Only apply Climara Pro to skin that is clean, dry, and free of any powder, oil, or lotion.

You should not apply the patch to injured, burned, or irritated skin, or areas with skin conditions (such as birthmarks, tattoos, or that is very hairy).

Press the patch firmly onto your skin.

Press the patch firmly in place with your fingers for at least 10 seconds.

Rub the edges of the patch to make sure that it will stick to your skin.

Note:

Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off.

If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your original application schedule.

If you stop using your Climara Pro or forget to apply a new patch as scheduled, you may have spotting, or bleeding, and your symptoms may come back.

Throwing away your used patch.

When it is time to change your patch, remove the old patch before you apply a new patch.

To throw away the patch, fold the sticky side of the patch together, place it in a sturdy, childproof container, and place this container in the trash. Used patches should not be flushed in the toilet.

How should I use
Climara Pro?

  • Use Climara Pro exactly as your Healthcare Provider tells you to use it.
  • Climara Pro is for skin use only.
  • Change your Climara Pro patch 1 time each week or every 7 days.
  • Apply your Climara Pro patch to a clean, dry area on your lower abdomen or buttocks. This area must be clean, dry, and free of powder, oil or lotion for your patch to stick to your skin.
  • Apply your Climara Pro patch to a different area of your abdomen or your buttocks each time. Do not use the same application site 2 times in the same week.
  • Do not apply Climara Pro to your breasts.
  • If you forget to apply a new Climara Pro, you should apply a new patch as soon as possible.
  • You and your Healthcare Provider should talk regularly (every 3 to 6 months) about the dose you are using and whether you still need treatment with Climara Pro.

How do I change
Climara Pro?

  • When changing Climara Pro, peel off the used patch slowly from the skin.
  • After removal of Climara Pro, people usually have either no adhesive residue or light adhesive residue. If any adhesive residue remains on your skin after removing the patch, allow the area to dry for 15 minutes. Then, gently rub the area with an oil-based cream or lotion to remove the adhesive from your skin.
  • Keep in mind, the new patch must be applied to a different skin area of your lower abdomen or buttocks. This area must be clean, dry, and free of powder, oil or lotion. The same site should not be used again for at least 1 week after removal of the patch.
  • Click here for full instructions in the full Prescribing Information.

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What is Climara Pro® Used For?

Climara Pro® contains two kinds of hormones, an estrogen and a progestin. It is used after menopause in women with an intact uterus to:

  • Reduce moderate to severe hot flashes
  • Help reduce your chances of getting osteoporosis (thin weak bones)
    • If you use Climara Pro only to prevent osteoporosis from menopause, talk with your Healthcare Provider about whether a different treatment or medicine without estrogens might be better for you.

Important Safety Information

What is the most important information I should know about Climara Pro® (combination of estrogen and a progestin)?

  • Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia.
  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Using estrogen-alone may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • You and your healthcare provider should talk regularly about whether you still need treatment with the Climara Pro.

Who should not use Climara Pro?

Do not use Climara Pro if you have had your uterus (womb) removed (hysterectomy). Climara Pro contains a progestin to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and should not use Climara Pro.

Do not start using Climara Pro if you:

Have unusual vaginal bleeding; currently have or have had certain cancers, such as cancer of the breast or uterus; had a stroke or heart attack; currently have or have had blood clots or liver problems; have been diagnosed with a bleeding disorder; are allergic to Climara Pro or any of its ingredients; or think you may be pregnant.

Before using Climara Pro, tell your Healthcare Provider if you:

Have any unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, or are breastfeeding.

What are possible side effects of Climara Pro?

Serious, but less common side effects of Climara Pro include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus (womb), cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, changes in your thyroid hormone levels and enlargement of benign tumors of the uterus (“fibroids”).

Call your Healthcare Provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

New breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches and severe pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Less serious, but common side effects include:

Headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection and redness or irritation at the patch placement site.

These are not all the possible side effects of Climara Pro. For more information, ask your Healthcare Provider or pharmacist. Tell your Healthcare Provider if you have any side effects that bother you or do not go away.

Climara Pro is available by prescription only.


For important risk and use information, including Boxed Warning, about Climara Pro, please see the Full Prescribing Information.